Prueba
Depict the biotransformation pathway of 2, 6-dinitrotoluene
1. Locate chemicals in liver and intestine.
Key: Microfloral nitroreductase activity occurs in the intestine.
Copy and paste the chemical species which could be transferred from intestine to liver, as done for the glucuronide conjugate from liver to intestine.
Increase liver and intestine object sizes and/or move arrows at convenience.
2. Locate chemicals between arrows in the biotransformation route.
3. Replace the gaps with the corresponding name of xenobiotic biotransformating enzymes in the biotransformation route: Cytochrome P450 (CYP), alcohol/aldehyde dehydrogenases, glucuronyl transferase, microfloral reductase, microfloral -glucuronidase, sulfotransferase, acetyl transferase.
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4. Which biotransformation reactions could generate carbonium and nitrenium ions and, consequently, initiate neoplasias? |
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5. What is the critical step of the 2,6-dinitrotoluene biotransformation route to produce carcinogenicity? |
